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PLA monofilament

Developing cutting-edge technologies and products for healthy beauty

PLA monofilament

PLA Lifting Thread


PLA Lifting Thread Advantages

PLA vs PDO


PDO (Polydioxanone)
PLA (Poly lactic Acid)
Efficacy
• Never been proven for the capability of neo-collagenesis in clinical trials (PDO is approved for use in suturing)

• Not desirable for Cog thread use due to its low elasticity and fast degradation in body

• Proven for neo-collagenesis ability through global clinical trials & currently being used as a main component of fillers following approval by the US FDA in 1999.

• Has much higher elasticity and tensile strength compared to PDO and desirable for Cog and Screw type threads


PDO
PLA
★ PLA Advantages (Compared to PDO)
Glass Transition Temp. (℃)
-10 ~ -5
60 ~ 65
- Higher thermal stability without changing structure in body temperature
Tensile Strength (Gpa)
1.5
2.7
- Higher tensile strength
- Higher elasticity
Lifting Duration (Months)
1.5
12~24
- Longer lifting duration in body

PDO (Polydioxanone)
PLA (Poly lactic Acid)
Efficacy Duration
• Partially degrading at 2 weeks following procedure and being fully degraded by 6 months
• Partially degrading at 3months following procedure along with collagenesis. PLA is fully transformed into collagen within 12 ~ 24 months.
Safety
• Safety of repetitive PDO use has not been proven
• The dye used in PDO thread, Violet No.2, which is also used industrially, may potentially cause pigmentation on the skin.
• PLA is naturally found in the body and has been approved by the US FDA for use as a filler component
• No accumulation of pigments
• Not harmful to the body

Violet No.2

D&C Violet 2 is a synthetic dye produced from petroleum or coal tar sources

German suture company, B.Braun website:

Dyed sutures are rarely used on the outer surface of the body, to avoid a tattoo effect.

PLA Types

1. PLA Mono type
• Long lasting Efficacy
- PLA Mono type maintains its form within the body for a much longer period of time and, therefore, shows longer lifting efficacy compared to PDO

• Strong NeoCollagenesis (same as PLA based dermal filler effect)
- Proven by the US FDA  as a main component of PLA based dermal fillers in the global market
- PDO only approved for suture and never proven for neo-collagenesis ability in clinical trials

2. PLA Cog type
• Strong Cog Effect
- PLA Cog type has stronger tensile strength and skin lifting ability compared to PDO (2-fold)

• Long Cog Effect
- PLA Cogs remain intact within the body for at least 12 months, maximizing the lifting efficacy (PDO Cogs partially degraded within 2weeks after procedure)

3. PLA Screw type
• Strong Volumizing Effect
- Current PDO screw type threads have lower tensile strength and elasticity and, therefore, have limitations in providing volumizing efficacy
 - PLA screw type threads, however, have high tensile strength and elasticity, leading to strong volumizing effects and also efficacy in neocollagensis (indications: undereye hollow, nasolabial folds)

• Strong Elasticity
- Due to high elasticity, PLA can maintain screw structure rigidly